Lawes was captain for the win against Wales last month, and he keeps his place this weekend.
"Ireland are the most cohesive side in the world right now and it will be a good test this weekend.
“We’ve prepared really well for this game. We did some good team togetherness work in Bristol and had a solid week of training on the pitch here.
“We are looking forward to going after them in front of a great home crowd at Twickenham.
"It’s been special having 82,000 supporters back in for our Six Nations games and it will be a great Test match for them.”
England: Steward; Malins, Marchant, Slade, Nowell; Smith, Randall; Genge, George, Sinckler; Itoje, Ewels; Lawes, Curry, Simmonds.
Replacements: Blamire, Marler, Stuart, Launchbury, Dombrandt, Youngs, Ford, Daly.
Ireland: Keenan; Conway, Ringrose, Aki, Lowe; Sexton (c), Gibson-Park; Healy, Sheehan, Furlong; Beirne, Ryan; O'Mahony, van der Flier, Doris.
Replacements: Herring, Kilcoyne, Bealham, Henderson, Conan, Murray, Carbery, Henshaw.