There are four changes to the pack that started the 35-20 defeat at Mattioli Woods Welford Road, with Manny Iyogun and Ehren Painter both coming into the front row.
Alex Waller and Paul Hill drop to the bench, along with lock Api Ratuniyarawa, who is replaced in the second row by Brandon Nansen.
Scrum-half Tom James has been added to the unavailable list, meaning Frank Lomani is on the bench.
As for Sale, they are without Manu Tuilagi, who is on England duty.
But Alex Sanderson is still able to name a formidable team, making just three changes from the win against Worcester Warriors last weekend.
New signing, former Saints lock Dom Barrow, is among the replacements as he gets set to make his Sale debut.
Saints: Hutchinson; Sleightholme, Proctor, Dingwall (c), Skosan; Furbank, Mitchell; Iyogun, Matavesi, Painter; Ribbans, Nansen; Wilkins, Harrison, Augustus.
Replacements: Haywood, Waller, Hill, Ratuniyarawa, Coles, Lomani, Grayson, Francis.
Sale Sharks: S James; Roebuck, R du Preez, van Rensburg, Reed; MacGinty, Quirke; Harrison, Langdon, Oosthuizen; Wiese, JP du Preez; JL du Preez, Ross (c), D du Preez.
Replacements: Taylor, McIntyre, Jones, Barrow, Nield, de Klerk, Doherty, McGuigan.