Police were called to the A6003, near Barford Bridge, after a crash on the stretch heading towards Kettering just before 8am.
The crash involved a Vauxhall Corsa and a Jaguar and left both vehicles needing to be recovered.
The Jaguar suffered extensive damage to its front end with the Corsa seen facing the wrong way on the verge.
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Police blocked part of the road with traffic slow moving past the scene.
A police spokesman said there was not believed to be any injuries.