England trio Dylan Hartley, Courtney Lawes and Tom Wood are named in the starting 15, alongside Wales wing George North.
But Luther Burrell, who missed training earlier in the week, will not be in the matchday squad.
Tom Stephenson again deputises for Burrell, while Lee Dickson is preferred to Kahn Fotuali’i at nine.
Saints had last weekend off after losing out in the LV= Cup semi-final at Saracens on the previous Saturday and they will be eager to hit top gear ahead of a crucial Champions Cup quarter-final at Clermont Auvergne on April 4.
Meanwhile, Wasps, who are also in European action, at Toulon, next weekend, are missing several key men.
Fly-half Andy Goode will play no part at the Gardens, with England flanker James Haskell also absent.
One man who will start is James Downey, with the former Saints favourite lining up at 12.
Saints: Wilson; K Pisi, G Pisi, Stephenson, North; Myler, Dickson; Corbisiero, Hartley (c), Ma’afu; Lawes, Day; Wood, Clark, Manoa.
Replacements: Haywood, A Waller, Denman, Fisher, Dickinson, Fotuali’i, Waldouck, Tuala.
Wasps: Miller; Wade, Daly, Downey, Tagicakibau; Lozowski, Simpson; Mullan (c), Shervington, Cittadini; Gaskell, Myall; Johnson, Young, N Hughes.
Replacements: McIntyre, Swainston, Gaskell, Jackson, Thompson, G Hughes, Helu.