A limited number of Falcons supporters will be able to attend the Kingston Park clash, which has been moved to Monday, May 17 (kick-off 7.30pm).
The reason it has been switched from the weekend is because Government Covid-19 rules are set to change on May 17.
“The Government has indicated – as part of their Spring Roadmap – that supporters may be allowed to attend sporting fixtures from May 17," explained Phil Winstanley, the rugby director at Premiership Rugby.
"By moving matches into midweek we are ready to welcome fans back if it is decided that it is safe to do so.
“We’d like to thank BT Sport and the clubs involved for their co-operation in making these changes which we hope will lead to thousands of our supporters seeing Premiership Rugby live in May.
“BT Sport have also confirmed they will show all matches live.”
Saints, who last played in front of supporters when they hosted Bordeaux on December 11, are hoping to welcome up to 4,000 fans for their final two home games, against Wasps and Exeter Chiefs, on May 29 and June 6 respectively, however there are no guarantees as yet.