Harlequins v Northampton Saints: Full team news for Saturday's game

Langdon has not played since having thumb surgery after being forced off during the first half of the Investec Champions Cup quarter-final defeat at Bath on April 10.

But the England hooker is now ready to make his comeback and will wear the No.2 shirt at the Twickenham Stoop.

Cleopas Kundiona and Tom James are also back from injury, with Kundiona starting at tighthead and James among the replacements.

Jonny Weimann gets the start at scrum-half, with Archie McParland among a raft of players rested.

Tom Pearson and Tom Litchfield are the only men who started in last Saturday’s 36-32 win against Gloucester who remain in the starting line-up this weekend.

Anthony Belleau replaces Fin Smith at fly-half, while Fraser Dingwall comes in to skipper the side from centre.

James Martin gets a chance on the wing, with England Under-20s ace James Pater at full-back.

JJ van der Mescht returns to the second row after being rested, with Josh Kemeny back in the back row after his breather against Gloucester.

Sonny Tonga’uiha is primed to make his PREM debut from the bench.

Ollie Sleightholme has been added to the unavailable list, which also contains the names of Trevor Davison, Alex Mitchell, Henry Lumley, Freddie St John, Edoardo Todaro and Charlie Ulcoq.

As for Harlequins, they have made five changes after losing 26-12 at Saracens last weekend.

Stephan Lewies will run out at the Stoop for one final time as he returns from injury to be named in the second row.

Elsewhere in the pack, tighthead Ollie Streeter is set for his first PREM start after a series of impressive performances as a replacement. The 19-year-old joins Will Hobson and Sam Riley in the front row.

Jonny Green is named in the engine room alongside Lewies, while Will Evans comes into the back row after a strong showing at StoneX Stadium.

Jack Kenningham switches to the blindside and Alex Dombrandt, who swept the board at Quins awards do, remains at No.8.

Scrum-half Will Porter continues his starting run after returning from injury to partner Marcus Smith in the half-backs.

Bryn Bradley starts at 12, while Cadan Murley switches to outside centre for Saturday's contest.

Cassius Cleaves steps into the starting 15 on the left wing after involvement in the wider matchday squad last week.

Cameron Anderson continues to operate on the right wing, with Jamie Benson starting at full-back for his final game in the quarters.

Jimmy Staples is set for his second PREM appearance as a replacement, and Los Pumas duo Boris Wenger and Pedro Delgado will provide prop reinforcements.

A trio of back-five forwards return from injury for the final round as Kieran Treadwell, Guido Petti Pagadizábal and Tom Lawday are all included in the wider matchday squad.

Centurion Lawday will feature for Quins one final time after seven seasons at the Stoop.

Stu Townsend is named as replacement scrum-half, while Josh Bellamy is set for his PREM debut when introduced.

Harlequins: 15 Jamie Benson; 14 Cameron Anderson, 13 Cadan Murley, 12 Bryn Bradley, 11 Cassius Cleaves; 10 Marcus Smith, 9 Will Porter; 1 Will Hobson, 2 Sam Riley, 3 Ollie Streeter; 4 Jonny Green, 5 Stephan Lewies; 6 Jack Kenningham, 7 Will Evans, 8 Alex Dombrandt (c).

Replacements: 16 Jimmy Staples, 17 Boris Wenger, 18 Pedro Delgado, 19 Kieran Treadwell, 20 Guido Petti Pagadizábal, 21 Tom Lawday, 22 Stu Townsend, 23 Josh Bellamy.

Saints: 15 James Pater; 14 James Martin, 13 Tom Litchfield, 12 Fraser Dingwall (c), 11 James Ramm; 10 Anthony Belleau, 9 Jonny Weimann; 1 Danilo Fischetti, 2 Curtis Langdon, 3 Cleopas Kundiona; 4 Tom Lockett, 5 JJ Van Der Mescht; 6 Josh Kemeny, 7 Tom Pearson, 8 Sam Graham.

Replacements: 16 Craig Wright, 17 Tom West, 18 Sonny Tonga’uiha, 19 Chunya Munga, 20 Callum Chick, 21 Tom James, 22 Toby Thame, 23 George Hendy.