Academy product Lawes again lines up in the back row, with Tom Wood and Teimana Harrison also getting the nod.
Wood will be starting a game for the first time since the Premiership defeat to Saracens on September 2.
Jamal Ford-Robinson will start for the first time in Northampton colours as he replaces Kieran Brookes at tighthead.
Christian Day and API Ratuniyarawa make up a new-look second row partnership.
Piers Francis starts at fly-half for the first time since joining from the Blues, while Nic Groom replaces Cobus Reinach at scrum-half.
Harry Mallinder comes in for Ahsee Tuala at full-back, while Nafi Tuitavake is named at outside centre.
Tom Collins replaces the injured George North on the wing.
Saints: Mallinder; Foden, Tuitavake, Burrell, Collins; Francis, Groom; Waller, Hartley (c), Ford-Robinson; Ratuniyarawa, Day; Lawes, Wood, Harrison.
Replacements: Haywood, van Wyk, Brookes, Paterson, Gibson, Reinach, Stephenson, Pisi.
Clermont Auvergne: Toeva; Strettle, Penaud, Lamerat, Raka; Lopez, Parra: Chaume, Kayser, Slimani, van der Merwe, Timani, Cancoriet, Lee, Lapandry.
Replacements: Uluigia, Falgoux, Jarvis, Jedrasiak, Gerondeau, Cassang, Betham, Abendanon