According to odds the Scottish singer is 3/1 favourite to claim more awards at the glitzy bash than any other attendees.
Grime artist Dave is also nominated in four categories, including British Male Solo Artist and Best New Artist.
Singer-songwriter Mabel will also have high hopes of heading home with silverware - she's nominated in three categories and is backed at 10/1 to win more awards than any other performer.
'Lewis Capaldi is going to clean up'
Bathgate performer Capaldi, who is set to perform at the ceremony, is favourite in all four categories that he is nominated in.
Jessica O'Reilly of Ladbrokes has backed the artist to claim all four awards while lending support to Mabel and Billie Eilish.
She said: "It looks like Capaldi is going to clean up at the Brits this year, while Mabel and Billie Eilish are the most likely female winners in a male-dominated line-up of nominees."
In the Album of the Year category, Capaldi faces arguably his stiffest competition in the form of Dave. His debut studio album Psychodrama earned wide acclaim and picked up the Mercury Prize in 2019. Fellow grime artist Stormzy will be looking to add to his 2018 success - his debut album Gang Signs and Prayer won in the category and his second effort Heavy Is The Head is listed at 5/1 to triumph.
One artist guaranteed to win on the night is 25-year-old singer Celeste who was already named as the victor in the Rising Star Award category. Fred Again meanwhile claimed victory in the British Producer of the Year category.
Lewis Capaldi 4/5Stormzy 3/1Dave 4/1Harry Styles 6/1Michael Kiwanuka 10/1
Mabel 10/11Charlie XCX 4/1FKA Twigs 5/1Mahalia 10/1Freya Ridings 12/1
Foals 6/4Bastille 3/1Coldplay 7/2D Block Europe 10/1BMTH 20/1
Song of the Year
Lewis Capaldi 1/2Mabel 3/1Dave 5/1Calvin Harris and RagnBone Man 6/1Stormzy 7/1Mark Ronson and Miley Cyrus 10/1Ed Sheeran and Justin Bieber 10/1Tom Walker 14/1AJ Tracey 20/1
Album of the Year
Lewis Capaldi 5/6Dave 7/4Stormzy 5/1Harry Styles 6/1Michael Kiwanuka 10/1
Lewis Capaldi 5/4Dave 2/1Mabel 4/1Sam Fender 10/1Aitch 20/1
Billie Eilish 4/5Lizzo 2/1Camilla Cabello 7/2Ariana Grande 6/1Lana Del Rey 8/1
Post Malone 2/1Tyler the Creator 3/1Dermot Kennedy 4/1Bruce Springsteen 5/1Burna Boy 10/1