Diggers move on April 19 to upgrade traffic signals on the A4500 Wellingborough Road, between Abington Park and Weston Favell Shopping Centre.
Traffic on Booth Lane South and Westone High Street will also be affected with 24-hour temporary traffic lights on the four-way junction.
A spokesperson for Northamptonshire Highways delivery partners KierWSP confirmed the completion date for work is June 3.
They added: "Works include renewal of the exiting traffic signals and renewal of road markings.
"These works will improve future traffic flow at the junction.
"We promise to minimise disruption but there will be prolonged delays so please allow additional time when travelling.
"There will be temporary crossings with marshals on site to assist pedestrians."