Rectory Road has been closed with Northamptonshire Police urging people to avoid the area in an appeal at about 6pm.
The Northants Road Crime Team are conducting an investigation at the site, which is cordoned off.
Details on the severity of any injuries suffered or the vehicles involved in the crash are yet to be confirmed.
On social media the Northants Road Crime Team issued a 'polite request' for people to stop moving their cones at the crash site.
They said: "They are there for a reason to protect the scene and officers working there.
"The road will be open as soon as we can get on with our investigation."