The northbound and southbound carriageways near junction 19 are currently closed to allow two air ambulance helicopters to land.
The Highways Agency has reported that the collision, at around 3.20pm, involved four lorries and a car.
At around 3.30pm Northamptonshire Fire and Rescue tweeted that it was attending the scene due to individuals being trapped in the vehicles.
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Northamptonshire’s Roads Policing Unit has reported that the trapped people have since been released from the vehicles.