A police spokesperson said the unknown offenders broke in to the Newlands centre between 11.30pm yesterday (Tuesday) and 12.30am this morning (Wednesday).
They smashed a window and then gained entry to seven stores in the centre in Tanner Lane, Kettering.
The police said the burglars stole a number of items, including cash and jewellery.
The centre is still open and shoppers walking through will notice that Boots, Pep & Co, Goldsmiths, Eurochange and an ATM cashpoint have all been affected.
A spokesperson for the centre declined to comment.
Police are appealing for any witnesses or anyone with information to call Northamptonshire Police on 101.