The air ambulance has been called to a serious crash which has closed the A43 near Kettering this afternoon.
Police are currently dealing with the incident and both carriageways are currently closed at Barford Bridge.
The incident, which took place on the stretch travelling from Stanion towards Kettering, took place just after 2pm.
It involved a car and a lorry and the driver of the car, a woman, has been seriously hurt.
Truck driver dies after crash near Northamptonshire border
Meet 105-year-old Marjorie - who must be Kettering's oldest property landlady
Who's been sentenced from Kettering, Raunds and Wellingborough
Corby man given suspended sentence after showing 'gun' to group in pub
'It's been a blast': pub legend Malcolm the Fish Man retires
A force spokesman said: "Motorists are advised to avoid the area while we deal with this incident.
"Thank you for your patience."
The road is expected to be closed for at least the next hour.