Foden was forced off with a groin injury at Saracens last weekend, while Fotuali’i is also ruled out.
That means Tom Kessell will start at nine, with no scrum-half cover on the bench.
Saints remain without Dylan Hartley and Lee Dickson due to concussion, while George North is still sidelined with a knee injury and Jamie Gibson is out with an ankle problem.
Wood returns after missing the game at Saracens, and the England flanker will captain Saints.
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Brookes comes in for Hill, who is on the bench, while Ahsee Tuala returns from injury to take Foden’s place at full-back.
Leicester have fewer injury worries and can boast a backline that contains the likes of Ben Youngs, Vereniki Goneva and Manu Tuilagi.
Saints: Tuala; K Pisi, G Pisi, Burrell, Elliott; Myler, Kessell; A Waller, Haywood, Brookes; Craig, Day; Lawes, Wood (c), Harrison.
Replacements: Marshall, Ma’afu, Hill, Matfield, Nutley, Hanrahan, Mallinder, Collins.
Leicester: Tait; Veainu, Betham, Tuilagi, Goneva; Burns, B Youngs; Ayerza, Thacker, Cole; Barrow, Kitchener; Fitzgerald, O’Connor, McCaffrey.
Replacements: Bateman, Mulipola, Balmain, Slater, Croft, Harrison, Williams, Thompstone.