Burrell and Brookes linked up with their country after last Sunday’s defeat at Newcastle Falcons, but both were let go on Tuesday evening.
Burrell takes his place in a backline that shows two changes from the 26-25 loss at Kingston Park.
James Wilson and Jamie Elliott miss out, meaning Ken Pisi and Tom Collins return.
Victor Matfield replaces Christian Day in the second row, while the fourth change comes at No.8, where Teimana Harrison comes in for Sam Dickinson.
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Worcester include three former Saints players in their squad.
GJ van Velze skippers the Warriors, who beat Northampton 13-12 on the opening night of the Aviva Premiership season, while Phil Dowson and Ryan Lamb are on the bench.
The Warriors are unchanged after their victory against Sale Sharks at Sixways last weekend.
Saints: Foden; K Pisi, Burrell, Mallinder, Collins; Myler, Dickson (c); A Waller, Haywood, Brookes; Craig, Matfield; Gibson, Wood, Harrison.
Replacements: Marshall, E Waller, Denman, Dickinson, Fisher, Kessell, Hanrahan, G Pisi.
Worcester: Pennell; Heem, Olivier, Mills, Vuna; Heathcote, Hougaard; Rapava Ruskin, Bregvadze, Schonert; O’Callaghan, Barry; Potgieter, Kirwan, van Velze (c).
Replacements: Annett, Leleimalefaga, Johnston, Dowson, Baldwin, Lamb, Symons.