Saints will be without Alex Corbisiero for their game at Gloucester as the England prop is being rested as part of the EPS agreement.
Corbisiero’s absence leaves the door open for Alex Waller, who is one of three changes to the team which won at Harlequins last Friday.
Sam Dickinson and Jamie Elliott also come into the starting line-up, in place of Courtney Lawes and Ken Pisi, who are on the bench.
Young prop Ethan Waller, brother of Alex, is given his chance on a replacements list that includes Phil Dowson, Lee Dickson and George Pisi.
Saints: Foden; Elliott, Wilson, Burrell, North; Myler, Fotuali’i; A Waller, Hartley (c), Mercey, Manoa, Day, Wood, Clark, Dickinson.
Replacements: Haywood, E Waller, Denman, Lawes, Dowson, L Dickson, K Pisi, G Pisi.
Gloucester: Cook; Sharples, Trinder, Twelvetrees, Simpson-Daniel; Burns, Cowan; Murphy, Dawidiuk, Harden, Savage (c), Stooke, Kvesic, Qera, Kalamafoni.
Replacements: Britton, Thomas, Knight, James, Morgan, Robson, Tindall, May.