Quins claimed a huge win in Coventry last weekend, scoring six tries in a stunning 49-17 success.
With Wasps shorn of several Six Nations players and some injured stars, Saints may also fancy their chances of an away win, especially as they go into the game on the back of two victories of their own.
And in the build-up to the game, attack coach Vesty insists it's vital that his side stick to what they are good at, rather than simply using Harlequins as a blueprint.
“It's really important that you know what you're good at and you do what you're good at,” Vesty said.
“Exeter have stuck to their guns and done what they're really good at and been very successful, Sarries are the same.
“We like to play up-tempo and play a high-speed game and we're not emulating anyone when we try to put that on a team.
“We'll concentrate on making our game as good as we can.
“Obviously we watch all the other games and take things out of those, and it was an exciting game, but you go back to what Quins did, they kicked the ball out of their own half the majority of the time and they put them under pressure to get the ball back.
“They played some sensible rugby and took their opportunities.
“As soon as they sniffed any weakness in the defence, they exploited it.
“What they didn't do is just joue, Marcus Smith kicked really well, they chased really hard, they did the basics to allow them to go and score tries.
“That's what good rugby is about.”