Tom Wood scored the most dramatic try of them all in the play-off semi-final success against Leicester Tigers in May 2014
And ahead of Saturday's huge final-four clash with Exeter Chiefs at Sandy Park, we take a look back at the black, green and gold's six previous ventures into the Premiership's end-of-season shootout.
Soane Tonga'uiha and Brian Mujati scored for Saints, but they were edged out late on by Saracens as Glen Jackson's nerveless penalty won the game at Franklin's Gardens, leaving Ben Foden (pictured) and Co deflated.
It was a hugely controversial east midlands clash at Welford Road as Leicester secured a seventh successive Premiership final appearance. Manu Tuilagi punched Chris Ashton in the face but both players were yellow carded by Wayne Barnes.
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Saints suffered more play-off semi-final misery as they threw away a 23-15 lead in the final 10 minutes of the match. Lee Dickson's try and six Ryan Lamb penalties made up the away side's tally at the Stoop.
Brian Mujati, Jamie Elliott (pictured) and GJ van Velze scored for Saints as they stunned Saracens at Allianz Park. Saints stormed into a 17-0 lead and completed the job as they finally secured a place in the final, where they lost to Leicester.
In the most memorable play-off semi-final of them all, Saints saw off Tigers thanks to Tom Wood's dramatic late try. Salesi Ma'afu was sent off for punching Tom Youngs, but Saints won and went on to claim their first Premiership title.
Saints finished top of the Premiership table for the first time, but they suffered defeat in the home semi-final against Saracens, despite a penalty try, an effort from Tom Wood and 14 points from the boot of Stephen Myler.