Northampton travel to Allianz Park off the back of a bonus-point win at Bristol last Sunday, and the only change sees hooker Dylan Hartley miss out.
The England captain, who has been struggling with a back strain, is not included in the matchday 23, and his place in the first XV is taken by Mike Haywood.
Haywood replaced Hartley at half-time in last Sunday’s victory at Ashton Gate, and Charlie Clare takes his spot on the replacements’ bench.
Saints team: Tuala; K Pisi, G Pisi, Burrell, North; Myler, Dickson; Waller, Haywood, Brookes, Lawes, Paterson, Wood, Harrison, Picamoles.
Replacements: Clare, Ma’afu, Hill, Dickinson, Gibson, Groom, Mallinder, Foden
Saracens team: Goode; Ashton, Bosch, Barritt, Wyles; Lozowski, Wigglesworth; M Vunipola, Brits, Du Plessis, Itoje, Hamilton, Rhodes, Burger, B Vunipola
Replacements: George, Barrington, Figallo, Brown, Wray, Spencer, Taylor, Maitland