Both Jack Brooks and Chaminda Vaas will miss Northamptonshire’s Clydesdale Bank 40 outing against Sussex at Hove on Sunday.
The new ball pairing are suffering from Achilles and back injuries respectively and will not be risked.
The only change to the bowling attack will see Andrew Hall replace David Burton meaning that Ollie Stone will keep his place.
On the batting side of things, the Steelbacks will go into the contest with the same top five who faced Derbyshire last week.
Talking about the line-up, interim head coach David Ripley commented: “Jack’s not going to be fit so he won’t be playing.
“Chaminda is suffering with his back and although he could possibly do with a bowl, we’ve got to try and find a balance between getting him right and giving him the right amount of match time.
“(Andrew) Hall comes back in and Ollie Stone will get another run out which is good for him.”
The Steelbacks will come up against a strong Sussex side who are having a good season, especially in the white ball formats.
They have won all of their CB40 games that have beaten the weather, and top the group as a result, and are due to host Gloucestershire in the last eight of the Friends Life t20 on Tuesday evening and Ripley is expecting a difficult encounter.
He added: “They’re very consistent in all formats of the game and in one-day cricket are always there or thereabouts.
“They’re a couple of wins from qualifying (for the semi-finals) and they win the majority of games they play.
“I’ve no doubt that it will be a tough game for us but that should give the lads added incentive to do well.”