The opening of the new site just off the A14 at Islip will create hundreds of jobs, with vacancies including shift managers and team managers.
Anyone interested in applying to work there can go along to a recruitment event in Kettering next month to find out more or apply online.
A spokesman for Primark said: “Primark is delighted to be opening a distribution centre in Islip, Northamptonshire.
“The warehouse covers 1.1 million sq ft.
“The opening of the site will create over 200 new positions through 2016 including shift managers, team managers and depot colleagues.
“Facilities for employees will include a café with hot and cold food service, a pool table, table football, WiFi access, a fitness room and 500 parking spaces.
“Primark will host an open day at Corn Market Hall in Kettering on Wednesday, March 9, from 10am to 4pm offering the chance for people to find out more about available vacancies for the distribution centre.
“You can also apply for these positions at Primark.com/search-and-apply.”
Kettering Council is supporting the event by providing the venue for the day.
Alex Jelley, economic regeneration manager at Kettering Council, said: “We are delighted to be supporting this event, although Kettering benefits from having a high employment rate it also has a growing work age population.
“Kettering Borough Council is committed to working with partners, neighbouring authorities and the business community to promote and encourage local employment opportunities for its residents to help build a more diverse, dynamic and self-reliant economy; one which is not overly dependent on in or out commuting.”
The opening of the new Islip site comes as the Primark centre 35 miles away at Magna Park in Lutterworth is due to close.
Speaking last year, a spokesman for Primark said the transfer of operations from Magna Park to Islip was due to take place by the middle of this year with a view to ceasing activity at Magna Park by September 2016.
The distribution centre in Thrapston will continue to operate in conjunction with the new Islip depot.
It is hoped the move to Islip will provide the budget fashion store with essential capacity and flexibility for growth.