Taylar Hutchins, aged 15, has links to the Northamptonshire area as well as Alfreton in Derbyshire.
She is described as five feet five inches tall and slim. She has very long black hair and a tanned complexion. When she was last seen, yesterday afternoon (Wednesday June 8), she was wearing pink shorts, a long white polo shirt and black Ugg boots.
Officers believe she is with a man she knows, who picked her up in his vehicle.
Anyone who sees Taylar or who knows where she is should ring Derbyshire police on 101.