Transport minister Justine Greening will officially signal the start of work on the £34m A43 Corby link road this week.
The minister will attend a sod-cutting ceremony on Thursday to mark the start of construction on the four-mile dual carriageway, which will connect the A43 near Stanion to the A6003 near Barford Bridge.
The Government is contributing £20.6m to the scheme and Northamptonshire County Council the remaining £13.4m.
Ms Greening said: “The new Corby link road is a double win for Northamptonshire - improving journeys between the A43 and other major routes in Northamptonshire, as well as reducing congestion on smaller local roads and bringing relief to nearby villages.
“A strong transport network is vital in helping to boost business both regionally and nationally - that is why we are putting £20.6m into this scheme as part of this government’s commitment to drive growth in the economy and reduce congestion on our roads.”
County council leader Jim Harker said: “This is a major project for Northamptonshire and absolutely key in helping create the conditions to bring economic growth particularly in the north of the county.
“I’m delighted that the secretary of state is coming here to help us officially start work on the project and pleased that we have such a strong endorsement of the scheme.”
Last month, the county council appointed a contractor – Interserve Construction Limited – and the new road should open to traffic in early 2014.