The country’s two biggest teaching unions are holding a one-day strike tomorrow, Tuesday, October 1.
Northamptonshire County Council says parents will be told by their children’s schools whether or not they are open.
The authority said each head teacher will make a decision on whether to close or partially close their school on the basis of their staffing levels.
Bishop Stopford School in Kettering is one which will be partly closing.
It will remain open for Year 11 and the sixth form, but will be closed for Years 7 to 10.
Headteacher Margaret Holman said in a letter to parents that more than 50 members of staff could take part in the strike action.
The two unions, the NUT and NASUWT, are walking out over pay, pensions and workloads.
A national strike before Christmas is being threatened, with tomorrow’s action being limited to the east of England, the Midlands, Yorkshire and the Humber region.
There will be another regional strike on 17 October in London, North East, South East and South West.
Teachers have accused the government of “reckless and irresponsible behaviour” and say Education Secretary Michael Gove has refused to engage in meaningful negotiations.
The Government says such strikes will disrupt pupils’ learning, inconvenience parents and damage the reputation of teachers.
Mr Gove said: “I unhesitatingly condemn this action.”