The eastbound stretch of the A45 remains closed between Great Billing and Earls Barton following the earlier accident.
One man has been airlifted to hospital following the crash at around 11.40am.
Severe delays built as a result of the closure with miles of tailbacks which left vehicles stranded.
By around 3pm, Northamptonshire Police had successfully turned around all the vehicles which were stuck within the closure.
PC 1604 Scott tweeted: "The road will remain closed for sometime however due to needing to he resurfaced."
Drivers are reporting that all surrounding routes are extremey busy.