More than 800 people in Northamptonshire die from heart disease every year.
New figures have been published by the British Heart Foundation (BHF) to raise awareness for National Heart Month.
On average, East Northamptonshire sees the highest number of deaths from heart disease, with 129 people dying from it every year.
BHF local fundraising volunteer manager Nigel Cole said: “The figures published in our Coronary Heart Disease Statistics 2012 give a snapshot of the state of the nation’s heart health.
“These show that every year more than 68,500 men and women in England lose their lives to heart disease – the country’s single biggest killer.
“Cardiovascular disease can affect anyone, young and old, perhaps a baby born with a hole in the heart or a friend or colleague who suffers a heart attack.
“Whether you have high blood pressure or high cholesterol we are working to ensure these conditions can one day be eliminated.”
On average 805 people in the county die from heart disease every year, with 66 of these in Corby, 101 in Kettering and 108 in Wellingborough.
To support the fight against it, BHF is urging people in Northamptonshire to join in National Wear Red Day on Friday, February 24, to help raise vital funds.
And BHF’s mascot, Mr Hearty, has been out in the county shaking his collection bucket this week.
Mr Cole said: “We need to raise money in Northamptonshire to help care for people with heart disease, to support their families, to campaign on their behalf and to fund pioneering research to save lives.
“Please help, we need your donations or time and money now.”