If your camera has a built-in flash and you are taking pictures inside, try turning it off.
Modern cameras are getting much better in low light situations, and unless you are going for a particular look you should end up with a much more pleasing image with your flash turned off.
If you have a separate flash gun attached to your camera, and it allows you to, always try to bounce the flash of off the ceiling or wall to get a much softer diffused light.
Please bear in mind that if the wall or ceiling is a strong colour, your image will be biased towards that colour – you can of course use this in a creative way.
In short, except in exceptional circumstances, never use direct flash.
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