Saints centre Luther Burrell will make his England debut in Saturday’s Six Nations opener against France in Paris.
Burrell is one of four changes from the England team that lost 30-22 to New Zealand at Twickenham in November, with club-mate Lee Dickson one of the unlucky ones to miss out.
Dickson is replaced at scrum-half by Harlequins’ Danny Care, with the Saints man dropping to the bench.
Burrell will still have three Saints club-mates alongside him at the Stade de France though, as Dylan Hartley, Tom Wood and Courtney Lawes all start.
“We can’t wait for Saturday,” said England head coach Stuart Lancaster.
“We’ve had a good two weeks and all the players have pushed hard for selection.”
England: Mike Brown; Jack Nowell, Luther Burrell, Billy Twelvetrees, Jonny May; Owen Farrell, Danny Care; Joe Marler, Dylan Hartley, Dan Cole, Joe Launchbury, Courtney Lawes, Tom Wood, Chris Robshaw, Billy Vunipola.
Replacements: Tom Youngs, Mako Vunipola, Henry Thomas, Dave Attwood, Ben Morgan, Lee Dickson, Brad Barritt, Alex Goode.