George North and Alex Corbisiero are in line to make their first appearance in Saints colours at Franklin’s Gardens on Friday night.
The Lions duo have been named on the bench for the clash with RaboDirect PRO12 outfit Edinburgh (kick-off 7.30pm).
Saints have named a strong squad, with Tom Wood skippering the starting side and the likes of Stephen Myler and Lee Dickson also playing for the first time during pre-season.
New prop Gareth Denman, a summer recruit from Rotherham, is among the replacements following his try-scoring debut in the 45-21 win at Bedford last Friday night.
But Kahn Fotuali’i, who starred in that success, Salesi Ma’afu, Glenn Dickson and Rob Verbakel will not be involved.
Saints: Foden; K Pisi, G Pisi, Burrell, Elliott; Myler, Dickson; A Waller, Haywood, Mercey; Lawes, Day; Clark, Wood (c), van Velze.
Replacements: McMillan, Corbisiero, Denman, Craig, Nutley, Dowson, Dickinson, Glynn, Olver, Wilson, Stephenson, North, Collins, Diggin.