Saints youngsters Alex Day and Ethan Waller will make their first senior starts for the club in Sunday’s LV= Cup showdown at London Irish.
Scrum-half Day made a two-try scoring debut from the bench in the bonus win over Gloucester last weekend, and is promoted to the starting line-up for his efforts.
And Ethan Waller will wear the number one shirt for the first time on his ninth appearance for the first team as one of six changes to the starting line-up from last weekend.
His brother Alex drops out of the matchday 23.
Tom Collins, who made his first team debut at the Madejski in the Premiership two weeks ago, returns to the wing with Ken Pisi on Samoa duty, and Waller is part of an all new front row, with Ross McMillan and Salesi Ma’afu in from the off.
There is experience in the team as well, and Christian Day will also partner Rob Verbakel in the second row as the Saints go looking for a second win at the home of the Exiles in a fortnight after a 19-16 Premiership triumph earlier this month.
Among the replacements, Academy wing Josh Skelcey is a possible senior debutant, while Gareth Denman and Calum Clark also come into the matchday squad.
Dom Waldouck will once again skipper the side from the centres.
Saints team to play London Irish, LV= Cup, Madejski Stadium, Sunday, November 17th, 2013 (ko 3pm): James Wilson; Howard Packman, Tom Stephenson, Dom Waldouck, Tom Collins; Glenn Dickson, Alex Day; Ethan Waller, Ross McMilln, Salesi Ma’afu, Rob Verbakel, Christian Day, Ben Nutley, Teimana Harrison, GJ van Velze.
Replacements: Matt Williams, Gareth Denman, Tom Mercey, Alex Woolford, Calum Clark, Ryan Glynn, Sam Olver, Josh Skelcey