Wellingborough led at half-time through Callum Dench.
But Ise turned in a superb secon-half performance to turn the game around with goals from Ryan Kenyon, Joe Tilley and Jayden Walker.
Wellingborough Town: Jacob Adamson, Nyam Bailey, Charlie Baxter, Alex Cafferkey-Cameron, Callum Dench, Jared Dwaine, Harry Ferguson, Denver Harrold, Max Jeffery, Connor Oxlade, Tyrese Parris-Smith, Dante Pinard, Kevin Takyi, Thomas Tuthill, James Wallis. Wellingborough Town player of the match: Tyrese Paris-Smith.
Ise Lodge: Matthew Ellis, Luke Hayward, Ryan Hawthorn, Adam Honour, Perry Jacob, Ryan Kenyon, Declan McInnes, Reuben McInnes, Jack Price, Dale Sanderson, Callum Summers, Joe Tilley, Jayden Walker, Kelsey Walsh, Jack Watson. Ise Lodge player of the match: Jack Price.