Nearly 60 bags of rubbish were collected in just two days by Kettering Council staff working on the A14.
Dedicated staff from the council’s environmental care team were out on the grass verges between junctions 10 and 11 on Monday and Tuesday, near the village of Cranford.
And over the course of the clean-up, staff filled 57 bags of rubbish and also disposed of one tyre.
The council’s environmental team puts 300 man hours every year into planned clean-ups of the busy dual carriageway.
Head of environmental care Brendan Coleman said: “We do regular planned cleans on this road and we do reactive cleans as well.
“We also have four bins in all the lay-bys.
“Clearly what we would like people to do is not drop litter. Take it home or put it in the bins provided – look after the environment a bit more.
“The amount of litter we are moving this year is a lot less than it was.
“We want to try and keep our patch as clean as possible but we need people to work with us.
“We really do go the extra mile and the team are a really dedicated bunch.”
Mr Coleman said he wanted to work more closely with the Highways Agency and other authorities to co-ordinate litter picking work for maximum benefit.
The litter pick follows another two-day operation last month along the stretch of the A43 which links the A14 to the A6003, which led to 120 bags of rubbish being collected.
Kettering Council cleared about 1,200 bags of rubbish from beside main roads in 2010 and about half that amount in 2011.
It is responsible for the A14 from near the Kelmarsh exit at junction two to around Thrapston at junction 13.