Five people were taken to hospital after a serious accident involving two cars in Northamptonshire on Sunday night.
The incident happened on the A45 between Earls Barton and Great Doddington and the A45 was then closed in both directions from Great Billing to Wilby Way.
Police are appealing for witnesses after a silver Volkswagen Jetta crossed the westbound carriageway over the central reservation into the eastbound carriageway before colliding with a blue Honda Civic travelling eastbound.
Passengers from both vehicles and the driver of the blue Honda Civic sustained serious injuries in the collision, which happened at about 8.20pm.
Anyone with information or who witnessed this incident is asked to call the Drivewatch Hotline on 0800 174615.
A spokesman for Northamptonshire Fire and Rescue said: “We attended a road traffic accident involving two vehicles.
“Both vehicles were made safe. Five casualties were conveyed to hospital. None of them were trapped.”